Hassan Khan made his List-A debut in the 2016 Pakistan Cup. Prior to his debut, he was named in Pakistan & squad for the 2016 Under 19 Cricket World Cup. He made his Twenty20 debut for Quetta Gladiators in Pakistan Super League in 2017. He made his first class debut for Karachi Whites and got awarded the Quaid-e-Azam Trophy.  Khan has also served as the captain of Pakistan & squad for Under-19 Cricket World Cup (2018).  He was named in Khyber Pakhtunkhwa & squad for the 2018 Pakistan Cup and was selected to play for the Edmonton Royals in the players & draft for the inaugural edition of the Global T20 Canada tournament.